• Rhön-Klinikum announced recruitment has started for the randomized PRO-HYPO prostate cancer radiotherapy study at its Marburg ion-beam center.
• No results have been presented yet; the trial will track side effects, quality of life, and longer-term outcomes over five years.
• The study aims to determine whether hypofractionated proton therapy reduces bowel and bladder complications versus hypofractionated IMRT photon therapy.
• Enrollment targets 202 men with non-metastatic disease receiving radiation as primary treatment, supporting positioning for proton therapy capacity utilization.

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