• HSS researchers found knee shape independently influences anterior cruciate ligament loading, potentially supporting more personalized injury prevention and surgical planning.
• Results were published in Communications Medicine, based on MRI-derived computer models of 168 young, active individuals.
• Knee shape produced greater ligament loading in previously injured athletes than controls, with females experiencing higher loading overall than males.
• The findings could help identify higher-risk knees, but researchers cannot yet assign individual athletes an injury risk score.

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