PASADENA, Calif. (AP) — PASADENA, Calif. (AP) — Arrowhead Research Corp. (ARWR) on Thursday reported a loss of $428 million in its fiscal fourth quarter.

On a per-share basis, the Pasadena, California-based company said it had a loss of $3.04.

The results fell short of Wall Street expectations. The average estimate of nine analysts surveyed by Zacks Investment Research was for a loss of $1.59 per share.

The drug developer posted revenue of $37.8 million in the period, which also missed Street forecasts. Seven analysts surveyed by Zacks expected $66.3 million.

For the year, the company reported that its loss widened to $724.2 million, or $5.11 per share. Revenue was reported as $450.8 million.

Arrowhead Research shares have declined 29% since the beginning of the year. In the final minutes of trading on Thursday, shares hit $47.15, a rise of 14% in the last 12 months.

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This story was generated by Automated Insights (http://automatedinsights.com/ap) using data from Zacks Investment Research. Access a Zacks stock report on ARWR at https://www.zacks.com/ap/ARWR