• Ionis Pharmaceuticals director Michael R. Hayden reported purchasing 5,000 common shares through his spouse at $29.64 per share.
• Following the purchase, Hayden held 27,000 shares indirectly through his spouse, with direct holdings of 54,298 shares.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission (Ref. ID: 0000874015-26-000273), on November 13, 2026, and is solely responsible for the information contained therein.